Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri
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منابع مشابه
Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri
Phyllanthus niruri is a plant with medicinal properties. It is often used to treat mild malaria and the elimination of renal stones. However, studies on its toxicity are scarce. The study was carried out to determine if the aqueous leaf extract of P. niruri administered to female Sprague-Dawley rats would illicit evidence of toxicity. Fifteen female rats weighing 150-200 g were divided into 3 g...
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In modern era, plant extracts are being used extensively as a source of medicinal agents. However, there is limited data available about the toxicity of herbal products used in remedies, are essential for the study of toxicity profile of medicinal plants. Therefore, aim of this study was to observe the biochemical and histopathological changes in liver due to acute oral toxicity of aqueous leaf...
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Various doses of the aqueous extract of Phyllanthus amarus (AEPA) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. The extract caused a significant (P < 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. The inhibition produced by 200 mg/kg AEPA (70.20%) was significantly hi...
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Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective potential of aqueous extract of the herb Phyllanthus niruri (PN) on NIM-induced oxidative stress in vivo using a murine model, by determining the activities of hepatic anti-oxida...
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The main objective of this study is to evaluate the gastroprotective activity of the Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats. Six groups of Wistar rats were pretreated, respectively, with distilled water; omeprazole 20 mg/kg; and 250, 500, 750 and 1000 mg/kg P. niruri leaf extract 30 min before oral administration of absolute ethanol to generate ga...
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ژورنال
عنوان ژورنال: Interdisciplinary Toxicology
سال: 2011
ISSN: 1337-9569,1337-6853
DOI: 10.2478/v10102-011-0031-9